Package insert for Calmactiva CBD oil
Package insert for Calmactiva CBD oil
Product information
- Product name: Calmactiva CBD oil
- Active ingredients: Cannabidiol (CBD), Cannabigerol (CBG), Cannabidivarin (CBDV).
- Concentrations: 10%, 20%, 30%
- Contents: 10 ml - 250-300 drops
General Safety Profile
CBD is generally considered safe and has a good tolerability profile. Studies have shown that most people tolerate CBD well, even at high doses. The World Health Organization (WHO) has also noted that there is no evidence of abuse or dependence on CBD.
Ingredients per product
- 10% CBD oil:
- MCT oil (coconut oil).
- CBD- 1000 MG CBD -10.91%
- THC 0.08%
- CBN 0.29%
- CBG 0.34%
- CBDV 0.06%
- Natural flavor
- 20% CBD oil:
- MCT oil (coconut oil)
- CBD- 2000 mg CBD -20.90%
- THC 0.08%
- CBN 0.30%
- CBG 0.34%
- CBDV 0.06%
- Natural flavor
- 30% CBD oil:
- MCT oil (coconut oil)
- CBD 3000 mg -30.90%
- THC 0.08%
- CBN 0.31%
- CBG 0.34%
- CBDV 0.06%
- Natural flavor
What is Calmactiva CBD oil?
Calmactiva CBD oil is a dietary supplement that contains cannabidiol (CBD), a non-psychoactive compound extracted from the hemp plant (Cannabis sativa). CBD is popular because of its potential health benefits, including support for stress, anxiety, and sleep problems. The product is designed for daily use and can contribute to overall well-being.
What are Cannabinoids?
Cannabinoids are natural compounds found in the cannabis plant. The most well-known are THC (tetrahydrocannabinol), which is psychoactive, and CBD (cannabidiol), which is non-psychoactive. CBD interacts with the body's endocannabinoid system, which plays a role in several physiological processes, including pain, mood, and sleep.
Application
Calmactiva CBD oil is intended for:
- Reducing stress and anxiety
- Improving sleep quality
- Supporting general well-being
- Promotion of a sense of relaxation
- Supporting overall mood
Not intended for:
- Diagnosing, treating or curing disease.
- Replacing medication without consulting a health care provider.
Dosage
Recommended dosage:
- 10% CBD oil:
Start with 1-3 drops per day. Increase dose gradually as needed.
20% CBD oil:
Start with 1-2 drops per day. Increase dose gradually as needed.
- 30% CBD oil:
Start with 1 drop per day. Increase dose gradually as needed.
Max 6-8 drops spread over 24 hours.
Administration
Drip the oil under the tongue and hold for 30-60 seconds before swallowing. This promotes its absorption into the bloodstream. The oil can also be mixed with water or other liquids, but effectiveness may be reduced when diluted.Note:
It may take several days to weeks before you begin to notice the effects of CBD. It is recommended to maintain a consistent dosage for best results.
Drug interactions
Here is a comprehensive list of medications with which CBD may not interact well, including details on the mechanisms of interaction and the possible consequences. This can help users better understand what to look out for when considering CBD in combination with other medications.
1. Blood thinners
- Warfarin: CBD can affect the metabolism of warfarin by inhibiting the cytochrome P450 enzyme system. This can lead to increased levels of warfarin in the blood, which can increase the risk of bleeding. Regular monitoring of INR (International Normalized Ratio) is necessary for patients taking both.
- Acenocoumarol: Another anticoagulant that may be affected by CBD, with possible increases in bleeding time.
- Fenprocoumon: This drug can also be affected by CBD, which can lead to similar risks as with warfarin.
2. Antidepressants
- SSRIs (selective serotonin reuptake inhibitors):
- Fluoxetine (Prozac): CBD can increase serum levels of fluoxetine, which can lead to side effects such as drowsiness and an increased risk of serotonin syndrome (a potentially life-threatening condition).
- Sertraline (Zoloft): Similar interactions may occur, with CBD increasing the effectiveness and side effects of sertraline.
- TCAs (tricyclic antidepressants):
- Amitriptyline: CBD may affect the metabolism of amitriptyline, leading to increased side effects such as drowsiness, confusion and anticholinergic effects (e.g., dry mouth, constipation).
- Nortriptyline: Interactions are similar to those of amitriptyline, and monitoring may be required.
3. Antipsychotics
- Risperidone: CBD can increase plasma and brain levels of risperidone, which can lead to sedation and other side effects such as extrapyramidal symptoms (movement disorders).
- Clozapine: This drug can also be affected by CBD, which can lead to increased side effects, especially in patients with a history of using multiple antipsychotics.
4. Anticonvulsants
- Phenobarbital: CBD can increase the effectiveness of phenobarbital, which can lead to excessive sedation and central nervous system depression.
- Phenytoin: The combination may lead to changes in the effectiveness of phenytoin, resulting in increased side effects or increased risk of seizures.4. Anticonvulsants
- Phenobarbital: CBD may increase the effectiveness of phenobarbital, which may result in excessive sedation and central nervous system depression.
- Phenytoin: The combination may lead to changes in the effectiveness of phenytoin, resulting in increased side effects or increased risk of seizures.
5. Cardiac medications
- Beta blockers:
- Propranolol: CBD can lower blood pressure and enhance the effects of propranolol, which can lead to hypotension (low blood pressure) and bradycardia (slow heart rate).
- Atenolol: Again, CBD may enhance blood pressure-lowering effects, with possible side effects.
- Calcium antagonists:
- Verapamil: CBD can affect the metabolism of verapamil, which can lead to increased levels of the drug and side effects such as decreased heart rate and hypotension.
- Diltiazem: Similar interactions may occur, with increased side effects when using both substances.
6. Immunosuppressants
- Ciclosporin: CBD can affect the metabolism of ciclosporin, leading to increased serum levels and a greater risk of side effects such as kidney damage.
- Tacrolimus: Another immunosuppressant that can be affected by CBD, which can increase effectiveness and worsen side effects.
7. Antiviral medications.- Ritonavir: This drug, used to treat HIV, may be affected by CBD, leading to increased side effects and potentially dangerous interactions.
- Lopinavir: The combination may reduce the effectiveness of antiviral treatment or increase side effects.
8. Drugs used to treat cancer
- Chemotherapy:
- Doxorubicin: CBD can affect the breakdown of doxorubicin, which can lead to increased side effects such as cardiotoxicity.
- Paclitaxel: This drug can also be affected by CBD, which can increase side effects and affect efficacy.
9. Herbal medicines
- St. John's wort: This herb may accelerate the metabolism of CBD and other drugs, leading to decreased effectiveness of both CBD and other drugs metabolized by the cytochrome P450 system.
10. Other medications
- Omeprazole: This medication may be affected by CBD, leading to increased side effects and changes in effectiveness.
- Sildenafil (Viagra): CBD can affect the breakdown of sildenafil, which can lead to increased side effects such as headaches and decreased blood pressure.
11. Opioids
- Oxycodone and Morphine: CBD can enhance the sedative effects of opioids, which can lead to an increased risk of respiratory depression and other serious side effects.
12. Diabetes medication
- Metformin: CBD may affect the effectiveness of metformin, leading to changes in blood sugar levels.
Concluding remark
Because of the potential for interactions between CBD and a wide range of medications, it is crucial that users consult with a health care provider before taking CBD, especially if they are taking other medications. This helps minimize potential side effects and unwanted effects and ensures that medications can be used safely and effectively. It is also important to re-evaluate regularly, especially if there are changes in medication or health status.
Caution:
Inform your doctor of all medications you are taking, including over-the-counter drugs and dietary supplements, to avoid possible interactions.
Alcohol Consumption
It is generally not recommended to combine CBD with alcohol. Both substances can have a sedative effect, which can lead to increased drowsiness, sedation and other unwanted side effects. If you choose to use them together, start with low amounts of both and always consult a health care provider.
Side effects
CBD is generally well tolerated, but some users may experience side effects, such as:
- Fatigue: Some users report increased feelings of fatigue.
- Dry mouth: A common side effect of CBD use.
- Changes in appetite: Some people experience an increase or decrease in appetite.
- Diarrhea: In rare cases, users may experience stomach upset or diarrhea.
Contact a health care provider if side effects persist or worsen.
Overdose
There have been no reported cases of death from CBD overdose, but it is possible to experience side effects at extremely high doses. It is always recommended to start with a low dose and gradually increase it under the supervision of a healthcare provider.
Insufficient Research.
Although CBD is considered safe, it is important to note that much is still unknown about the long-term effects and safety of CBD, especially at high doses or with long-term use. More clinical research is needed to understand the safety and effectiveness of CBD in different populations and for different conditions.
Expected Effects
The effects of CBD are usually not immediate. It may take 14 to 28 days before you begin to experience significant results. It is important to be patient and maintain a consistent dosage.Important:
CBD does not work in the same way as traditional painkillers such as paracetamol. It has a different mechanism of action and cannot be used as a substitute for these medications.
Warnings and precautions.
- Consult a doctor: Before using CBD oil, especially if you are pregnant, nursing, or taking any medications.
- Not suitable for persons under 18 years of age.
- Store in a cool, dry place: Out of the reach of children.
- Do not use CBD oil in combination with alcohol or other sedatives.
Shelf life
Check the expiration date on the package. Max 6 months shelf life after opening the bottle. Store the oil in a cool, dark place to maintain quality. Before use, always check for any changes in color or odor. Shake well before use.
Waste disposal
- Empty bottles: Make sure the bottle is completely empty before throwing it away. Rinse with water if necessary.
- Waste separation: Dispose of the bottle in the appropriate recycling bins for glass or plastic, depending on the material of the bottle.
Contact information
For questions or comments about this product, contact:
- Calmactiva Customer Service
- Email: info@calmactiva.com
- Phone: 0031650589123
Disclaimer
This product is not intended to diagnose, treat, cure or prevent diseases. The effectiveness of CBD may vary from person to person. Always consult a health care provider for medical advice.